VCA: Past, Present, and Future
Jean-Michel Dubernard, MD, PhD
University Lyon I
E. Herriot Hospital Lyon
Monday, June 4, 2018
10:15 am - 10:45 am
Jean-Michel (Max) Dubernard was trained in the Lyon Medical school where he used to work in a research laboratory specialized in liver transplantation. In 1965 he moved to Boston and worked with Joe Murray and his team as a Research fellow at the Harvard Medical School and a Clinical fellow at the Peter Bent Brigham Hospital (1965-1967). His favorite experimental work was the demonstration of the role of humoral antibodies in canine allograft rejection using an original experimental model. His MD thesis in France reported the Brigham’ experience in human renal transplantation. Back to France he prepared is PhD thesis in Transplantation immunology by working on the facilitation of xenograft renal transplants between two Primate species. With Jules Traeger, he developed the renal transplantation program at the Edouard Herriot Hospital in Lyon with some specific interest such as renal transplantation in children including a twelve days newborn, Koch pouches for urinary diversion in recipients without bladder, simultaneous renal and adrenal allograft….His research and clinical work on occlusion of the pancreatic duct aimed at converting a bifunctional into a monofunctional organ and at transplanting vascularized islets. This original technique took a significant place in the development of pancreatic transplantation in the mid-seventies and the early eighties. Close relations between the Munich, Stockholm, Cambridge and Minneapolis groups considerably helped to progress. His old dream of opening the way to Vascularized Composite Tissue Allografts came true with the first single (1998) and double(2000) hand allografts performed in close cooperation with the Sydney (Earl Owen), Milan and London teams as well as The first face transplantation (2005) performed in close cooperation with the Amiens (Bernard Devauchelle) and Brussels teams. He received the TTS Medawar prize in 2008.
Systems Immunology in Health and Disease
Mark M. Davis, PhD
Director of the Stanford Institute for Immunology, Transplantation and Infection (ITI)
Tuesday, June 5, 2018
9:30 am - 10:00 am
Dr. Mark M. Davis is the Director of the Stanford Institute for Immunology, Transplantation and Infection (ITI), a Professor of Microbiology and Immunology, and a Howard Hughes Medical Institute Investigator. He received a B.A. from Johns Hopkins University and a PhD from the California Institute of Technology. He later was a postdoctoral fellow and staff fellow at the Laboratory of Immunology at NIH and later became a faculty member in the Department of Microbiology and Immunology at Stanford University School of Medicine, where he remains today. Dr. Davis is well known for identifying many of the T-cell receptor genes, which are responsible for the ability of these cells to recognize a diverse repertoire of antigens. His current research interests involve understanding the molecular interactions that underlie T cell recognition and the challenges of human immunology, specifically a “systems level” understanding of an immune response to vaccination or infection.
He has received many honors and awards, including memberships in the National Academy of Science and the Institute of Medicine, The Paul Ehrlich Prize, The Gairdner Foundation Prize, The King Faisal Prize, the General Motors Alfred P. Sloan Prize, and being elected as Foreign Member to the Royal Society of London.